abstract：:Extracorporeal elimination of drugs and toxins is a critical component in the management of poisonings, though specific techniques and indications remain a matter of debate. Conventional hemodialysis is frequently the treatment of choice because of its widespread availability and proven effectiveness for certain drugs...

journal_title：Seminars in dialysis

authors： Goodman JW,Goldfarb DS

更新日期：2006-09-01 00:00:00

abstract：:Patients with end-stage renal disease (ESRD) develop hemostatic disorders mainly in the form of bleeding diatheses. Hemorrhage can occur at cutaneous, mucosal, or serosal sites. Retroperitoneal or intracranial hemorrhages also occur. Platelet dysfunction is the main factor responsible for hemorrhagic tendencies in adv...

journal_title：Seminars in dialysis

authors： Kaw D,Malhotra D

更新日期：2006-07-01 00:00:00

abstract：:With the current understanding that atherosclerosis is an inflammatory disorder, markers of the associated systemic inflammatory response have been extensively studied as predictors of cardiovascular disease. Recently the use of high-sensitivity C-reactive protein (hsCRP) has been proposed for risk assessment in indiv...

journal_title：Seminars in dialysis

authors： Rao M,Jaber BL,Balakrishnan VS

更新日期：2006-03-01 00:00:00

abstract：:Peritoneal dialysis (PD) is a markedly underutilized modality for permanent renal replacement therapy in the United States owing to a low rate of patient referral and high rate of patient dropout or transfer to hemodialysis. One cause for patient loss from PD is problematic PD catheters that often are removed rather t...

journal_title：Seminars in dialysis

authors： Asif A,Gadalean F,Vieira CF,Hogan R,Leon C,Merrill D,Ellis R,Amador A,Broche O,Bush B,Contreras G,Pennell P

更新日期：2006-03-01 00:00:00

abstract：:Patients undergoing chronic renal replacement therapy have a high incidence of dyslipidemia. In general, there are increased concentrations of triglyceride-rich apolipoprotein B-containing particles. These elevations lead to increased levels of non-high-density lipoprotein (HDL) levels. This pattern is further modifie...

journal_title：Seminars in dialysis

authors： Liu J,Rosner MH

更新日期：2006-01-01 00:00:00

abstract：:Kidney transplantation is the treatment of choice for most patients with end-stage renal disease (ESRD), with success rates greater than were envisioned as recently as a decade ago. Unfortunately this trend has created unprecedented demand for transplantable organs and new challenges for those desiring transplantation...

journal_title：Seminars in dialysis

authors： Gaston RS

更新日期：2005-11-01 00:00:00

abstract：:Most recent randomized controlled trials (RCTs) have found that hemodialysis graft surveillance combined with preemptive correction of stenosis does not prolong graft survival. Nevertheless, such programs may be justified if they reduce other adverse outcomes or decrease the cost of care. This study tested this hypoth...

journal_title：Seminars in dialysis

authors： Dossabhoy NR,Ram SJ,Nassar R,Work J,Eason JM,Paulson WD

更新日期：2005-11-01 00:00:00

abstract：:The treatment of end-stage renal disease (ESRD) makes extensive use of presterilized disposable items which, after use, are contaminated by blood. The preferred route of disposal of such items is by incineration. Disposal costs have risen and this increase in costs has not been matched by waste management programs in ...

journal_title：Seminars in dialysis

authors： Hoenich NA,Levin R,Pearce C

更新日期：2005-09-01 00:00:00

abstract：:Renal osteodystrophy (ROD) represents a spectrum of bone lesions ranging from a high-turnover to a low-turnover state. The expression of the histologic bone lesions is modulated by parathyroid hormone (PTH), vitamin D, calcium, phosphorus, and aluminum that act as major regulators of osteoblastic activity and bone for...

journal_title：Seminars in dialysis

authors： Hernandez JD,Wesseling K,Salusky IB

更新日期：2005-07-01 00:00:00

abstract：:A patient with newly diagnosed end-stage renal disease (ESRD) received a femoral catheter for hemodialysis (HD). Shortly thereafter he developed fever, and blood cultures grew methicillin-resistant Staphylococcus aureus. The catheter was removed and the patient was treated with both vancomycin and rifampin; however, b...

journal_title：Seminars in dialysis

authors： Chang CS,Thajeb P,Chen HH,Wu CJ

更新日期：2005-07-01 00:00:00

abstract：:With the increased number of renal transplants being performed in the United States, there are also increasing numbers of early and long-term allograft failures. Patients with failed allografts require reentry into the end-stage renal disease (ESRD) system. If an allograft is producing little in the way of morbidity, ...

journal_title：Seminars in dialysis

authors： Bennett WM

更新日期：2005-05-01 00:00:00

abstract：:As suggested by its American brand name (Sensipar), the calcimimetic cinacalcet sensitizes the parathyroid cells to the extracellular calcium signal, suppressing parathyroid hormone (PTH) release and synthesis and preventing parathyroid cell proliferation. This primary PTH suppression decreases the release of calcium ...

journal_title：Seminars in dialysis

authors： Shahapuni I,Mansour J,Harbouche L,Maouad B,Benyahia M,Rahmouni K,Oprisiu R,Bonne JF,Monge M,El Esper N,Presne C,Moriniere P,Choukroun G,Fournier A

更新日期：2005-05-01 00:00:00

abstract：:Physical, psychosocial, and lifestyle disturbances, along with physical and emotional symptoms, have been shown to impact the health-related quality of life (HRQOL) of those dependent on renal replacement therapy. The value of HRQOL measurement as a tool to improve clinical care has been recognized by patients, clinic...

journal_title：Seminars in dialysis

authors： Unruh ML,Weisbord SD,Kimmel PL

更新日期：2005-03-01 00:00:00

abstract：:Withdrawal from dialysis is an appropriate decision for situations in which the burdens of treatment outweigh the benefits. Alternately, it can be viewed as a public health problem and suicide equivalent that contributes to the high mortality of end-stage renal disease (ESRD). More than one in five deaths of patients ...

journal_title：Seminars in dialysis

authors： Cohen LM,Germain MJ

更新日期：2005-03-01 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO, epoetin) revolutionized the treatment of anemia in patients with chronic kidney disease (CKD) when it was approved for use in the United States in 1989. Among dialysis patients, the mean hemoglobin (Hb) in patients undergoing dialysis rose from 7-8 g/dl prior to 1989 to 11-12 ...

journal_title：Seminars in dialysis

authors： Berns JS

更新日期：2005-01-01 00:00:00

abstract：:To prevent pyrogenic reactions during hemodialysis, it is recommended that bacteria and endotoxin in dialysate not exceed 100-200 colony forming units (CFU)/ml and 0.25-2 endotoxin units (EU)/ml, respectively. While these limits are adequate to prevent acute pyrogenic reactions, data are accumulating to suggest they m...

journal_title：Seminars in dialysis

authors： Ward RA

更新日期：2004-11-01 00:00:00

abstract：:The National Kidney Foundation (NKF) has recently published clinical practice guidelines for bone metabolism and disease in chronic kidney disease (CKD) patients (the Kidney Disease Outcomes Quality Initiative [K/DOQI]). Data from the literature show that the majority of dialysis patients treated with traditional calc...

journal_title：Seminars in dialysis

authors： Uribarri J,National Kidney Foundation.

更新日期：2004-09-01 00:00:00

abstract：:Presternally exiting peritoneal dialysis (PD) catheters have been described as advantageous compared to abdominally exiting catheters with regard to infection, wound healing, and other complications. Placement of such catheters has only been described with open surgical techniques and not by percutaneous means. In thi...

journal_title：Seminars in dialysis

authors： Sreenarasimhaiah VP,Margassery SK,Martin KJ,Bander SJ

更新日期：2004-09-01 00:00:00

abstract：:The majority of end-stage renal disease (ESRD) patients are hypertensive. Drug therapy for hypertension in hemodialysis (HD) patients includes all classes of antihypertensive drugs, with the sole exception of diuretics. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers may decrease mo...

journal_title：Seminars in dialysis

authors： Hörl MP,Hörl WH

更新日期：2004-07-01 00:00:00

abstract：:The association of high body mass index (BMI) with better survival in chronic kidney disease (CKD) is considered a "risk factor paradox" or "reverse epidemiology." Since malnutrition is a powerful predictor of death and cardiovascular disease is its leading cause, it has been suggested that malnutrition and atheroscle...

journal_title：Seminars in dialysis

authors： Beddhu S

更新日期：2004-05-01 00:00:00

abstract：:Malnutrition is a frequent complication in hemodialysis patients and is associated with increased mortality and morbidity. Interventions such as oral or intravenous nutritional supplements have often failed to improve nutritional status. We report here the effect that daily dialysis, practiced in our center since 1997...

journal_title：Seminars in dialysis

authors： Galland R,Traeger J

更新日期：2004-03-01 00:00:00

abstract：:With the recent focus on the benefits of more frequent dialysis, the Baxter Aurora dialysis system provides maximum flexibility for therapy prescription, including short daily treatments, long nocturnal treatments, hemodialysis, hemofiltration, and online hemodiafiltration, all in a compact, reliable, easy to use syst...

journal_title：Seminars in dialysis

authors： Kelly TD

更新日期：2004-03-01 00:00:00

abstract：:Managing an end-stage renal disease (ESRD) patient is complex and presents many ethical challenges for the physician. Ownership of dialysis facilities has shifted over the past decade from largely nonprofit organizations to large companies whose shareholders are primarily interested in the profitability of their inves...

journal_title：Seminars in dialysis

authors： Bennett WM

更新日期：2004-01-01 00:00:00

abstract：:Determining dry weight and assessing extracellular fluid volume in hemodialysis (HD) patients is one of the greatest challenges to practicing nephrologists. The clinical examination has limited accuracy, so different strategies have been investigated to aid in this evaluation. Biochemical markers of volume overload (A...

journal_title：Seminars in dialysis

authors： Ishibe S,Peixoto AJ

更新日期：2004-01-01 00:00:00

abstract：:Depression has been documented as the most frequently encountered psychological problem in end-stage renal disease (ESRD) patients and has been correlated with both mortality and morbidity in these patients. Previous work by our group has shown that clinical depression is treatable with psychotropic medications in the...

journal_title：Seminars in dialysis

authors： Wuerth D,Finkelstein SH,Kliger AS,Finkelstein FO

更新日期：2003-11-01 00:00:00

abstract：:The rationale of temperature control during hemodialysis (HD) is to prevent heat accumulation, which increases body temperature and enhances hypotensive susceptibility. Treatments where thermal energy is neither delivered nor removed from the patient through the extracorporeal circulation (so-called extracorporeal the...

journal_title：Seminars in dialysis

authors： Schneditz D,Ronco C,Levin N

更新日期：2003-11-01 00:00:00

abstract：:Meta-analyses of the published literature are increasingly being used, allowing similar clinical trials to be combined quantitatively, thereby increasing the precision of the estimation of treatment effect. Four meta-analyses were recently published comparing the impact of dialysis membranes or dialysis modality on cl...

journal_title：Seminars in dialysis

authors： Teehan GS,Liangos O,Lau J,Levey AS,Pereira BJ,Jaber BL

更新日期：2003-09-01 00:00:00

abstract：:Pregnancy occurs uncommonly in women with chronic kidney disease (CKD) and fetal outcome tends to be poor, with high rates of prematurity and mortality. Dialysis, by complementing residual renal function, may improve fetal outcome in pregnant women with CKD. Although there are no prospective or randomized trials that ...

journal_title：Seminars in dialysis

authors： Shemin D

更新日期：2003-09-01 00:00:00

abstract：:Peritoneal dialysis (PD) is an underutilized form of renal replacement therapy. Recent data have emphasized that only 12% of end-stage renal disease (ESRD) patients are initiated on this form of therapy in the United States. Patients requiring PD have most often been referred to general surgeons for catheter placement...

journal_title：Seminars in dialysis

authors： Asif A,Byers P,Gadalean F,Roth D

更新日期：2003-05-01 00:00:00

abstract：:Cardiovascular complications are the leading cause of mortality in patients with end-stage renal disease (ESRD). The excess cardiovascular risk and mortality is already demonstrable in early renal disease and in patients with chronic renal failure (CRF), with the highest relative risk of mortality in the youngest pati...

journal_title：Seminars in dialysis

authors： London GM

更新日期：2003-03-01 00:00:00

abstract：:Growing evidence has been gathered over the last 15 years regarding the role of nontraditional or uremia-related risk factors in the pathogenesis of atherosclerosis in subjects with renal failure. Among those factors, dyslipidemia, inflammation, hyperhomocysteinemia, and oxidant stress have been extensively studied. H...

journal_title：Seminars in dialysis

authors： Madore F

更新日期：2003-03-01 00:00:00

abstract：:In an attempt to improve patient outcomes in peritoneal dialysis (PD), national organizations (such as the National Kidney Foundation Dialysis Outcomes Quality Initiative [NKF-DOQI] process) have formulated clinical practice guidelines based on clinical evidence available at the time of development. For "adequacy" of ...

journal_title：Seminars in dialysis

authors： Burkart JM

更新日期：2003-01-01 00:00:00

abstract：:There is abundant evidence that chronic renal failure (CRF) and end-stage renal disease (ESRD) alter drug disposition by affecting protein and tissue binding and reducing systemic clearance of renally cleared drugs. What is not fully appreciated is that CRF can significantly reduce nonrenal clearance and alter the bio...

journal_title：Seminars in dialysis

authors： Dreisbach AW,Lertora JJ

更新日期：2003-01-01 00:00:00

abstract：:Automated peritoneal dialysis (APD) has experienced significant growth in highly developed nations in the last few years, while in developing countries with important social, educational, and financial constraints this treatment modality is, at best, trying to emerge. APD offers advantages that make it popular. Some o...

journal_title：Seminars in dialysis

authors： Correa-Rotter R

更新日期：2002-11-01 00:00:00

abstract：:Few elderly patients with end-stage renal disease (ESRD) are treated with peritoneal dialysis (PD). Among dialysis patients >or=65 years of age reported by the U.S. Renal Data System (USRDS), the percentage treated with chronic peritoneal dialysis (CPD) is lower than in any other age group. To evaluate the effectivene...

journal_title：Seminars in dialysis

authors： Kadambi P,Troidle L,Gorban-Brennan N,Kliger AS,Finkelstein FO

更新日期：2002-11-01 00:00:00

abstract：:Both the morbidity of the uremic syndrome and the generation of uremic toxins are attributed to malnutrition. If protein intake and catabolism result in the generation of solutes, then nutritional intake should be related directly to toxicity. On the other hand, inadequate nutrition has been linked to inflammation and...

journal_title：Seminars in dialysis

authors： Vanholder R,Glorieux G,Lameire N

更新日期：2002-09-01 00:00:00

abstract：:This article reviews the pharmacokinetic characteristics of calcitriol, paricalcitol, and doxercalciferol, and provides an overview of the metabolism of vitamin D. Calcitriol and paricalcitol have similar pharmacokinetic profiles, with terminal half-lives ranging from 5 to 10 hours in healthy subjects to 15-30 hours i...

journal_title：Seminars in dialysis

authors： Bailie GR,Johnson CA

更新日期：2002-09-01 00:00:00

abstract：:The bone disease associated with end-stage renal failure (ESRD) and treatment are complex and multifactorial, and has changed in both clinical and imaging features over the past three decades. Whereas previously features of vitamin D deficiency (rickets/osteomalacia) and intense, and prolonged, secondary hyperparathyr...

journal_title：Seminars in dialysis

authors： Adams JE

更新日期：2002-07-01 00:00:00

abstract：:The etiology and management of intradialytic hypotension has become an increasingly complex issue. Volume depletion due to ultrafiltration remains the predominant underlying etiologic factor. However, patients vary markedly in their hemodynamic tolerance to fluid removal. While many risk factors have been identified, ...

journal_title：Seminars in dialysis

authors： Sherman RA

更新日期：2002-05-01 00:00:00

abstract：:Over the last 10 years an increasing number of patients worldwide have started dialysis or had transplantation. Many are elderly with complex comorbid conditions. Registries across the world all show a rapid and dramatic increase in the number of older patients accepted for renal replacement therapy. In addition, the ...

journal_title：Seminars in dialysis

authors： Krishnan M,Lok CE,Jassal SV

更新日期：2002-03-01 00:00:00